Weekly administration of sagopilone (ZK-EPO), a fully synthetic epothilone, in patients with refractory solid tumours: results of a phase I trial

BACKGROUND: Epothilones are a novel class of microtubule-stabilising agents, and sagopilone is a fully synthetic epothilone that has shown marked in vivo and in vitro preclinical activity. METHODS: This phase I, open-label study investigated the maximum tolerated dose (MTD) and dose-limiting toxicit...

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Bibliografiske detaljer
Main Authors: Arnold, D, Voigt, W, Kiewe, P, Behrmann, C, Lindemann, S, Reif, S, Wiesinger, H, Giurescu, M, Thiel, E, Schmoll, H-J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2009
Fag:
Clinical Study
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768435/
https://ncbi.nlm.nih.gov/pubmed/19773753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605327
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