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A Human Hepatocyte-Bearing Mouse: An Animal Model to Predict Drug Metabolism and Effectiveness in Humans

Preclinical studies to predict the efficacy and safety of drugs have conventionally been conducted almost exclusively in mice and rats as rodents, despite the differences in drug metabolism between humans and rodents. Furthermore, human (h) viruses such as hepatitis viruses do not infect the rodent...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Yoshizato, Katsutoshi, Tateno, Chise
פורמט: Artigo
שפה:Inglês
יצא לאור: Hindawi Publishing Corporation 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768028/
https://ncbi.nlm.nih.gov/pubmed/19884982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2009/476217
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