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A Human Hepatocyte-Bearing Mouse: An Animal Model to Predict Drug Metabolism and Effectiveness in Humans
Preclinical studies to predict the efficacy and safety of drugs have conventionally been conducted almost exclusively in mice and rats as rodents, despite the differences in drug metabolism between humans and rodents. Furthermore, human (h) viruses such as hepatitis viruses do not infect the rodent...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Hindawi Publishing Corporation
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2768028/ https://ncbi.nlm.nih.gov/pubmed/19884982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2009/476217 |
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