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On the Origin of the Catalytic power of Caboxypetidase A and Other Metalloenzymes
Zinc metalloenzymes play a major role in key biological processes and Carboxypeptidase-A (CPA) is a major prototype of such enzymes. The present work quantifies the energetics of the catalytic reaction of CPA and its mutants using the EVB approach. The simulations allow us to quantify the origin of...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2767396/ https://ncbi.nlm.nih.gov/pubmed/19480013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22466 |
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