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The Empirical Valence Bond as an Effective Strategy for Computer-Aided Enzyme Design

The ability of the empirical valence bond (EVB) to be used in screening active site residues in enzyme design is explored in a preliminary way. This validation is done by comparing the ability of this approach to evaluate the catalytic contributions of various residues in chorismate mutase. It is de...

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Bibliographic Details
Main Authors: Vardi-Kilshtain, Alexandra, Roca, Maite, Warshel, Arieh
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671572/
https://ncbi.nlm.nih.gov/pubmed/19229886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.200800299
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