Inhibition of p75 Neurotrophin Receptor Attenuates Isoflurane-mediated Neuronal Apoptosis in the Neonatal Central Nervous System

BACKGROUND: Exposure to anesthetics during synaptogenesis results in apoptosis and subsequent cognitive dysfunction in adulthood. Probrain derived neurotrophic factor (proBDNF) is involved in synaptogenesis and can induce neuronal apoptosis via p75 neurotrophic receptors (p75(NTR)). proBDNF is cleav...

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Bibliografische gegevens
Hoofdauteurs: Head, Brian P., Patel, Hemal H., Niesman, Ingrid R., Drummond, John C., Roth, David M., Patel, Piyush M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767332/
https://ncbi.nlm.nih.gov/pubmed/19293698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e31819b602b
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