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Docking and 3D-QSAR Studies on Isatin Sulfonamide Analogues as Caspase-3 Inhibitors
To provide insight of their inhibition mechanism and facilitate the design of more potent ligands, a series of 59 isatin sulfonamide analogues were docked to the X-ray structure of caspase-3, one of the important cysteine aspartyl-specific execution proteases in apoptosis, and their binding conforma...
Gorde:
Egile Nagusiak: | , , |
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Formatua: | Artigo |
Hizkuntza: | Inglês |
Argitaratua: |
2009
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Gaiak: | |
Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2767110/ https://ncbi.nlm.nih.gov/pubmed/19610597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci900144x |
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