Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2

Mutations of HFE are associated with hereditary hemochromatosis, but their influence on host susceptibility to infection is incompletely understood. We report that mice lacking one or both Hfe alleles are protected from septicemia with Salmonella Typhimurium, displaying prolonged survival and improv...

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Bibliographische Detailangaben
Hauptverfasser: Nairz, Manfred, Theurl, Igor, Schroll, Andrea, Theurl, Milan, Fritsche, Gernot, Lindner, Ewald, Seifert, Markus, Crouch, Marie-Laure V., Hantke, Klaus, Akira, Shizuo, Fang, Ferric C., Weiss, Günter
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2009
Schlagworte:
Phagocytes, Granulocytes, and Myelopoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766679/
https://ncbi.nlm.nih.gov/pubmed/19700664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-223354
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