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Is drug release necessary for antimicrobial activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally occurring salmycin “Trojan Horse” antibiotics and synthetic desferridanoxamine-antibiotic conjugates

The recent rise in drug resistance found amongst community acquired infections has sparked renewed interest in developing antimicrobial agents that target resistant organisms and limit the natural selection of immune variants. Recent discoveries have shown that iron uptake systems in bacteria and fu...

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Autors principals: Wencewicz, Timothy A., Möllmann, Ute, Long, Timothy E., Miller, Marvin J.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766516/
https://ncbi.nlm.nih.gov/pubmed/19221879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10534-009-9218-3
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