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Lethal Mutagenesis in Viruses and Bacteria
In this work we study how mutations that change physical properties of cell proteins (stability) affect population survival and growth. We present a model in which the genotype is presented as a set folding free energies of cell proteins. Mutations occur upon replication, so stabilities of some prot...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Genetics Society of America
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2766323/ https://ncbi.nlm.nih.gov/pubmed/19620390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.109.106492 |
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