Synthetic Analogs of FTY720 [2-Amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] Differentially Regulate Pulmonary Vascular Permeability in Vivo and in Vitro

Novel therapies are needed to address the vascular endothelial cell (EC) barrier disruption that occurs in inflammatory diseases such as acute lung injury (ALI). We previously demonstrated the potent barrier-enhancing effects of both sphingosine 1-phosphate (S1P) and the structurally similar compoun...

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Detalhes bibliográficos
Main Authors: Camp, S. M., Bittman, R., Chiang, E. T., Moreno-Vinasco, L., Mirzapoiazova, T., Sammani, S., Lu, X., Sun, C., Harbeck, M., Roe, M., Natarajan, V., Garcia, J. G. N., Dudek, S.M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766218/
https://ncbi.nlm.nih.gov/pubmed/19592667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.153544
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