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Highly Regio- and Stereoselective Synthesis of (Z)-Trisubstituted Alkenes via Propyne Bromoboration and Tandem Pd-Catalyzed Cross-Coupling

[Image: see text] Contrary to all previous reports, bromoboration of propyne with BBr(3) proceeds in ≥98% syn-selectivity to produce (Z)-2-bromo-1-propenyldibromoborane (1). Although 1 is readily prone to stereoisomerization, it can be converted to the pinacolboronate (2) of ≥98% isomeric purity by...

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Dettagli Bibliografici
Autori principali: Wang, Chao, Tobrman, Tomas, Xu, Zhaoqing, Negishi, Ei-ichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766167/
https://ncbi.nlm.nih.gov/pubmed/19694459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol901566e
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