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Dose-Dependent Effects of Runx2 on Bone Development
Runx2 controls the commitment of mesenchymal cells to the osteoblastic lineage. Distinct promoters, designated P1 and P2, give rise to functionally similar Runx2-II and Runx2-I isoforms. We postulate that this dual promoter gene structure permits temporal and spatial adjustments in the amount of Run...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Amer Soc Bone & Mineral Res.
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2765932/ https://ncbi.nlm.nih.gov/pubmed/19419310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.090502 |
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