Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice

Runx2 transcribes Runx2-II and Runx2-I isoforms with distinct N-termini. Deletion of both isoforms results in complete arrest of bone development, whereas selective loss of Runx2-II is sufficient to form a grossly intact skeleton with impaired endochondral bone development. To elucidate the role of...

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Bibliografiske detaljer
Main Authors: Xiao, Zhousheng, Awad, Hani A., Liu, Shiguang, Mahlios, Josh, Zhang, Shiqin, Guilak, Farshid, Mayo, Matthew S., Quarles, Leigh Darryl
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360182/
https://ncbi.nlm.nih.gov/pubmed/15936013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2005.04.028
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