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Nicotinamide phosphoribosyltransferase regulates cell survival through NAD(+) synthesis in cardiac myocytes
RATIONALE: NAD(+) acts not only as a co-factor for cellular respiration, but also as a substrate for NAD(+)-dependent enzymes, such as Sirt1. The cellular NAD(+) synthesis is regulated by both the de novo and the salvage pathways. Nicotinamide phosphoribosyltransferase (Nampt) is a rate-limiting enz...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2765790/ https://ncbi.nlm.nih.gov/pubmed/19661458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.203703 |
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