Estrogen Inhibits RANKL-stimulated Osteoclastic Differentiation of Human Monocytes through Estrogen and RANKL-regulated Interaction of Estrogen Receptor-α with BCAR1 and Traf6

The effects of estrogen on osteoclast survival and differentiation were studied using CD14-selected mononuclear osteoclast precursors from peripheral blood. Estradiol at ~1 nM reduced RANKL-dependent osteoclast differentiation by 40–50%. Osteoclast differentiation was suppressed 14 days after additi...

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Detalhes bibliográficos
Main Authors: Robinson, Lisa J., Yaroslavskiy, Beatrice B., Griswold, Reed D., Zadorozny, Eva V., Guo, Lida, Tourkova, Irina L., Blair, Harry C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765696/
https://ncbi.nlm.nih.gov/pubmed/19331827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2009.01.014
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