Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2

BACKGROUND AND PURPOSE: The lipid phosphatase known as SH2 domain-containing inositol 5′-phosphatase 2 (SHIP2) plays an important role in the regulation of the intracellular insulin signalling pathway. Recent studies have suggested that inhibition of SHIP2 could produce significant benefits in treat...

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Detalhes bibliográficos
Main Authors: Suwa, A, Yamamoto, T, Sawada, A, Minoura, K, Hosogai, N, Tahara, A, Kurama, T, Shimokawa, T, Aramori, I
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765606/
https://ncbi.nlm.nih.gov/pubmed/19694723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00358.x
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