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Stability of the Nicotine Metabolite Ratio in Ad Libitum and Reducing Smokers

BACKGROUND: The ratio of two nicotine metabolites, cotinine (COT) and trans-3′-hydroxycotinine (3-HC), has been validated as a method of phenotyping the activity of the liver enzyme cytochrome P450 (CYP) 2A6, and thus the rate of nicotine metabolism. Our objective was to evaluate the correlates and...

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Detalhes bibliográficos
Main Authors: Mooney, Marc E., Li, Zhong-ze, Murphy, Sharon E., Pentel, Paul R., Le, Chap, Hatsukami, Dorothy K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765478/
https://ncbi.nlm.nih.gov/pubmed/18559554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-08-0242
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