NLRP3 (NALP3/CIAS1/Cryopyrin) mediates key innate and healing responses to influenza A virus via the regulation of caspase-1

Virus-induced IL-1β and IL-18 production in macrophages is mediated via a caspase-1 pathway. Multiple microbial components, including viral RNA, are thought to trigger assembly of the cryopyrin inflammasome and consequent caspase-1 activation. Here we demonstrate that cryopyrin(−/−) and caspase-1(−/...

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Main Authors: Thomas, Paul G., Dash, Pradyot, Aldridge, Jerry R., Ellebedy, Ali H., Reynolds, Cory, Funk, Amy J., Martin, William J., Lamkanfi, Mohamed, Webby, Richard J., Boyd, Kelli L., Doherty, Peter C., Kanneganti, Thirumala-Devi
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765464/
https://ncbi.nlm.nih.gov/pubmed/19362023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.02.006
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