PTEN dosage is essential for neurofibroma development and malignant transformation

Patients with neurofibromatosis type 1 (NF1) carry approximately a 10% lifetime risk of developing a malignant peripheral nerve sheath tumor (MPNST). Although the molecular mechanisms underlying NF1 to MPNST malignant transformation remain unclear, alterations of both the RAS/RAF/MAPK and PI3K/AKT/m...

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Detalhes bibliográficos
Main Authors: Gregorian, Caroline, Nakashima, Jonathan, Dry, Sarah M., Nghiemphu, P. Leia, Smith, Kate Barzan, Ao, Yan, Dang, Julie, Lawson, Gregory, Mellinghoff, Ingo K., Mischel, Paul S., Phelps, Michael, Parada, Luis F., Liu, Xin, Sofroniew, Michael V., Eilber, Fritz C., Wu, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765459/
https://ncbi.nlm.nih.gov/pubmed/19846776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910398106
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