Pten Deletion in Adult Neural Stem/Progenitor Cells Enhances Constitutive Neurogenesis

Here we show that conditional deletion of Pten in a subpopulation of adult neural stem cells in the subependymal zone (SEZ) leads to persistently enhanced neural stem cell self-renewal without sign of exhaustion. These Pten null SEZ-born neural stem cells and progenies can follow the endogenous migr...

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Hauptverfasser: Gregorian, Caroline, Nakashima, Jonathan, Le Belle, Janel, Ohab, John, Kim, Rachel, Liu, Annie, Smith, Kate Barzan, Groszer, Matthias, Garcia, A. Denise, Sofroniew, Michael V., Carmichael, S. Thomas, Kornblum, Harley I., Liu, Xin, Wu, Hong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2009
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754186/
https://ncbi.nlm.nih.gov/pubmed/19211894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3095-08.2009
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