Inhibition of cellular alpha-glucosidases results in increased presentation of hepatitis B virus glycoprotein-derived peptides by MHC class I

Inhibitors of alpha glucosidases prevent the trimming of oligosaccharides on certain nascent glycoproteins, including the hepatitis B virus MHBs envelope glycoprotein. MHBs proteins with untrimmed oligosaccharides do not interact with calnexin, increasing protein misfolding and subsequent degradatio...

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Autores principales: Simsek, Ender, Sinnathamby, Gomathinayagam, Block, Timothy M., Liu, Yuanjie, Philip, Ramila, Mehta, Anand S., Norton, Pamela A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765373/
https://ncbi.nlm.nih.gov/pubmed/19091367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.11.027
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