Hepatitis B Virus Large and Middle Glycoproteins Are Degraded by a Proteasome Pathway in Glucosidase-Inhibited Cells but Not in Cells with Functional Glucosidase Enzyme

The secretion of hepatitis B virus (HBV) large (LHBs) and middle (MHBs) envelope polypeptides from tissue cultures requires proper protein folding and is prevented by inhibitors of the endoplasmic reticulum (ER) glucosidase. Using competitive inhibitors of the ER glucosidase, here it is shown that t...

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Detalhes bibliográficos
Main Authors: Simsek, Ender, Mehta, Anand, Zhou, Tianlun, Dwek, Raymond A., Block, Timothy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1235823/
https://ncbi.nlm.nih.gov/pubmed/16188993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.20.12914-12920.2005
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