Hepatitis B Virus Large and Middle Glycoproteins Are Degraded by a Proteasome Pathway in Glucosidase-Inhibited Cells but Not in Cells with Functional Glucosidase Enzyme

The secretion of hepatitis B virus (HBV) large (LHBs) and middle (MHBs) envelope polypeptides from tissue cultures requires proper protein folding and is prevented by inhibitors of the endoplasmic reticulum (ER) glucosidase. Using competitive inhibitors of the ER glucosidase, here it is shown that t...

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Hlavní autoři: Simsek, Ender, Mehta, Anand, Zhou, Tianlun, Dwek, Raymond A., Block, Timothy
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Genome Replication and Regulation of Viral Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1235823/
https://ncbi.nlm.nih.gov/pubmed/16188993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.20.12914-12920.2005
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