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Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing

T-cell receptor (TCR) genomic loci undergo somatic V(D)J recombination, plus the addition/subtraction of nontemplated bases at recombination junctions, in order to generate the repertoire of structurally diverse T cells necessary for antigen recognition. TCR beta subunits can be unambiguously identi...

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Autori principali: Freeman, J. Douglas, Warren, René L., Webb, John R., Nelson, Brad H., Holt, Robert A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765271/
https://ncbi.nlm.nih.gov/pubmed/19541912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.092924.109
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