The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

Loss of genomic integrity is a defining feature of many human malignancies, including human papillomavirus (HPV)-associated preinvasive and invasive genital squamous lesions. Here we show that aberrant mitotic spindle pole formation caused by abnormal centrosome numbers represents an important mecha...

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Hlavní autoři: Duensing, Stefan, Lee, Lily Y., Duensing, Anette, Basile, John, Piboonniyom, Siribang-on, Gonzalez, Sonia, Crum, Christopher P., Münger, Karl
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2000
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC27652/
https://ncbi.nlm.nih.gov/pubmed/10944189
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