The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

Loss of genomic integrity is a defining feature of many human malignancies, including human papillomavirus (HPV)-associated preinvasive and invasive genital squamous lesions. Here we show that aberrant mitotic spindle pole formation caused by abnormal centrosome numbers represents an important mecha...

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Main Authors: Duensing, Stefan, Lee, Lily Y., Duensing, Anette, Basile, John, Piboonniyom, Siribang-on, Gonzalez, Sonia, Crum, Christopher P., Münger, Karl
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC27652/
https://ncbi.nlm.nih.gov/pubmed/10944189
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