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Biochemical mechanisms in drug-induced liver injury: Certainties and doubts

Drug-induced liver injury is a significant and still unresolved clinical problem. Limitations to knowledge about the mechanisms of toxicity render incomplete the detection of hepatotoxic potential during preclinical development. Several xenobiotics are lipophilic substances and their transformation...

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Autors principals: Grattagliano, Ignazio, Bonfrate, Leonilde, Diogo, Catia V, Wang, Helen H, Wang, David QH, Portincasa, Piero
Format: Artigo
Idioma:Inglês
Publicat: The WJG Press and Baishideng 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764962/
https://ncbi.nlm.nih.gov/pubmed/19842215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.15.4865
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