Versatile Assays for High Throughput Screening for Activators or Inhibitors of Intracellular Proteases and Their Cellular Regulators

BACKGROUND: Intracellular proteases constitute a class of promising drug discovery targets. Methods for high throughput screening against these targets are generally limited to in vitro biochemical assays that can suffer many technical limitations, as well as failing to capture the biological contex...

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Główni autorzy: Hayashi, Hideki, Cuddy, Michael, Shu, Vincent Chih-Wen, Yip, Kenneth W., Madiraju, Charitha, Diaz, Paul, Matsuyama, Toshifumi, Kaibara, Muneshige, Taniyama, Kohtaro, Vasile, Stefan, Sergienko, Eduard, Reed, John C.
Format: Artigo
Język:Inglês
Wydane: Public Library of Science 2009
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764853/
https://ncbi.nlm.nih.gov/pubmed/19876397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007655
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