Versatile Assays for High Throughput Screening for Activators or Inhibitors of Intracellular Proteases and Their Cellular Regulators

BACKGROUND: Intracellular proteases constitute a class of promising drug discovery targets. Methods for high throughput screening against these targets are generally limited to in vitro biochemical assays that can suffer many technical limitations, as well as failing to capture the biological contex...

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Detalhes bibliográficos
Main Authors: Hayashi, Hideki, Cuddy, Michael, Shu, Vincent Chih-Wen, Yip, Kenneth W., Madiraju, Charitha, Diaz, Paul, Matsuyama, Toshifumi, Kaibara, Muneshige, Taniyama, Kohtaro, Vasile, Stefan, Sergienko, Eduard, Reed, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764853/
https://ncbi.nlm.nih.gov/pubmed/19876397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007655
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