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Exploring Molecular Mechanisms of Ligand Recognition by Opioid Receptors with Metadynamics

Opioid receptors are G protein-coupled receptors (GPCRs) of utmost significance in the development of potent analgesic drugs for the treatment of severe pain. An accurate evaluation at the molecular level of the ligand binding pathways into these receptors may play a key role in the design of new mo...

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Bibliografske podrobnosti
Main Authors: Provasi, Davide, Bortolato, Andrea, Filizola, Marta
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764813/
https://ncbi.nlm.nih.gov/pubmed/19785461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901494n
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