Comparison of Alzheimer Aβ(1–40) and Aβ(1–42) amyloid fibrils reveals similar protofilament structures

We performed mass-per-length (MPL) measurements and electron cryomicroscopy (cryo-EM) with 3D reconstruction on an Aβ(1–42) amyloid fibril morphology formed under physiological pH conditions. The data show that the examined Aβ(1–42) fibril morphology has only one protofilament, although two protofil...

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Bibliographic Details
Main Authors: Schmidt, Matthias, Sachse, Carsten, Richter, Walter, Xu, Chen, Fändrich, Marcus, Grigorieff, Nikolaus
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Physical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764733/
https://ncbi.nlm.nih.gov/pubmed/19843697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905007106
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