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Multiple B-vitamin inadequacy amplifies alterations induced by folate depletion in p53 expression and its downstream effector MDM2

Folate is required for biological methylation and nucleotide synthesis, aberrations of which are thought to be the mechanisms that enhance colorectal carcinogenesis produced by folate inadequacy. These functions of folate also depend on the availability of other B-vitamins that participate in “one-c...

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Autors principals: Liu, Zhenhua, Choi, Sang-Woon, Crott, Jimmy W., Smith, Donald E., Mason, Joel B.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764718/
https://ncbi.nlm.nih.gov/pubmed/18498130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.23599
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