Combined inadequacies of multiple B vitamins amplify colonic Wnt signaling and promote intestinal tumorigenesis in BAT-LacZ×Apc1638N mice

The Wnt pathway is a pivotal signaling cascade in colorectal carcinogenesis. The purpose of this work is to determine whether depletion of folate and other metabolically related B vitamins induces in vivo activation of intestinal Wnt signaling and whether this occurs in parallel with increased tumor...

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Hlavní autoři: Liu, Zhenhua, Ciappio, Eric D., Crott, Jimmy W., Brooks, Ryan S., Nesvet, Jared, Smith, Donald E., Choi, Sang-Woon, Mason, Joel B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2011
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157689/
https://ncbi.nlm.nih.gov/pubmed/21646397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-184143
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