Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling

BACKGROUND: The understanding of regulatory and signaling networks has long been a core objective in Systems Biology. Knowledge about these networks is mainly of qualitative nature, which allows the construction of Boolean models, where the state of a component is either 'off' or 'on&...

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Autores principales: Wittmann, Dominik M, Krumsiek, Jan, Saez-Rodriguez, Julio, Lauffenburger, Douglas A, Klamt, Steffen, Theis, Fabian J
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2009
Materias:
Methodology Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764636/
https://ncbi.nlm.nih.gov/pubmed/19785753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-3-98
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