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The Barrier to Enantiomerization and Dynamic Resolution of N-Boc-2-lithiopiperidine and the Effect of TMEDA

The kinetics of enantiomerization and dynamic thermodynamic resolution (DTR) of N-Boc-2-lithiopiperidine have been measured, revealing significant differences in enthalpy and entropy for these processes and a role for the achiral ligand TMEDA: the racemization and the DTR are catalytic and first ord...

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Bibliografiske detaljer
Main Authors: Coldham, Iain, Leonori, Daniele, Beng, Timothy K., Gawley, Robert E.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764334/
https://ncbi.nlm.nih.gov/pubmed/19707632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b911024k
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