Antihypertensive Pharmacogenetic Effect of Fibrinogen-beta Variant -455 G>A on Cardiovascular Disease, End-Stage Renal Disease and Mortality: The GenHAT Study

OBJECTIVE: The FGB gene codes for fibrinogen-beta, a polypeptide of the coagulation factor fibrinogen, which is positively associated with cardiovascular diseases. Studies show ACE inhibitors lower plasma fibrinogen concentrations, whereas diuretics and calcium channel blockers do not. Since carrier...

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Main Authors: Lynch, Amy I., Boerwinkle, Eric, Davis, Barry R., Ford, Charles E., Eckfeldt, John H., Leiendecker-Foster, Catherine, Arnett, Donna K.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764310/
https://ncbi.nlm.nih.gov/pubmed/19352213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32832a8e81
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