Antihypertensive Pharmacogenetic Effect of Fibrinogen-beta Variant -455 G>A on Cardiovascular Disease, End-Stage Renal Disease and Mortality: The GenHAT Study

OBJECTIVE: The FGB gene codes for fibrinogen-beta, a polypeptide of the coagulation factor fibrinogen, which is positively associated with cardiovascular diseases. Studies show ACE inhibitors lower plasma fibrinogen concentrations, whereas diuretics and calcium channel blockers do not. Since carrier...

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Hauptverfasser: Lynch, Amy I., Boerwinkle, Eric, Davis, Barry R., Ford, Charles E., Eckfeldt, John H., Leiendecker-Foster, Catherine, Arnett, Donna K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764310/
https://ncbi.nlm.nih.gov/pubmed/19352213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32832a8e81
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