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Antihypertensive Pharmacogenetic Effect of Fibrinogen-beta Variant -455 G>A on Cardiovascular Disease, End-Stage Renal Disease and Mortality: The GenHAT Study

OBJECTIVE: The FGB gene codes for fibrinogen-beta, a polypeptide of the coagulation factor fibrinogen, which is positively associated with cardiovascular diseases. Studies show ACE inhibitors lower plasma fibrinogen concentrations, whereas diuretics and calcium channel blockers do not. Since carrier...

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Detalhes bibliográficos
Main Authors: Lynch, Amy I., Boerwinkle, Eric, Davis, Barry R., Ford, Charles E., Eckfeldt, John H., Leiendecker-Foster, Catherine, Arnett, Donna K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764310/
https://ncbi.nlm.nih.gov/pubmed/19352213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32832a8e81
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