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Pharmacogenetic effect of the stromelysin (MMP3) polymorphism on stroke risk in relation to antihypertensive treatment: The GenHAT Study

BACKGROUND AND PURPOSE: Atherothrombotic diseases including stroke share a common etiology of atherosclerosis, and susceptibility to atherosclerosis has a genetic component. Stromelysin-1 (MMP3) regulates arterial matrix composition and is a candidate gene for atherothrombosis. A common polymorphism...

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Detalhes bibliográficos
Principais autores: Sherva, Richard, Ford, Charles E., Eckfeldt, John H., Davis, Barry R., Boerwinkle, Eric, Arnett, Donna K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859235/
https://ncbi.nlm.nih.gov/pubmed/21183746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.110.593798
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