A potential impact of DNA repair on ageing and lifespan in the ageing model organism Podospora anserina: Decrease in mitochondrial DNA repair activity during ageing

The free radical theory of ageing states that ROS play a key role in age-related decrease in mitochondrial function via the damage of mitochondrial DNA (mtDNA), proteins and lipids. In the sexually reproducing ascomycete Podospora anserina ageing is, as in other eukaryotes, associated with mtDNA ins...

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Main Authors: Soerensen, Mette, Gredilla, Ricardo, Müller-Ohldach, Mathis, Werner, Alexandra, Bohr, Vilhelm A., Osiewacz, Heinz D., Stevnsner, Tinna
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764052/
https://ncbi.nlm.nih.gov/pubmed/19486911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2009.05.003
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