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Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase
Both G- and V-type nerve agents possess a center of chirality about phosphorus. The S(p)-enantiomers are generally more potent inhibitors than their R(p)-counterparts toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). To develop model compounds with defined centers of chirality tha...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2763961/ https://ncbi.nlm.nih.gov/pubmed/19715346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900096j |
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