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Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase

Both G- and V-type nerve agents possess a center of chirality about phosphorus. The S(p)-enantiomers are generally more potent inhibitors than their R(p)-counterparts toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). To develop model compounds with defined centers of chirality tha...

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Detalhes bibliográficos
Main Authors: Barakat, Nora H., Zheng, Xueying, Gilley, Cynthia B., MacDonald, Mary, Okolotowicz, Karl, Cashman, John R., Vyas, Shubham, Beck, Jeremy M., Hadad, Christopher M., Zhang, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763961/
https://ncbi.nlm.nih.gov/pubmed/19715346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900096j
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