Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges

Serious adverse drug reactions (SADRs) are a major cause of morbidity and mortality worldwide. Some SADRs may be predictable, based upon a drug's pharmacodynamic and pharmacokinetic properties. Many, however, appear to be idiosyncratic. Genetic factors may underlie susceptibility to SADRs and t...

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Hlavní autoři: Wilke, Russell A., Lin, Debbie W., Roden, Dan M., Watkins, Paul B., Flockhart, David, Zineh, Issam, Giacomini, Kathleen M., Krauss, Ronald M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763923/
https://ncbi.nlm.nih.gov/pubmed/17971785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd2423
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