The 8q24 cancer risk variant rs6983267 demonstrates long-range interaction with MYC in colorectal cancer

An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that this region is a transcriptional enhancer, that the risk region physically interacts with the MYC proto-oncogene, and that the alleles of rs6983267 differentially bind t...

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Main Authors: Pomerantz, Mark M., Ahmadiyeh, Nasim, Jia, Li, Herman, Paula, Verzi, Michael P., Doddapaneni, Harshavardhan, Beckwith, Christine A., Chan, Jennifer A., Hills, Adam, Davis, Matt, Yao, Keluo, Kehoe, Sarah M., Lenz, Heinz-Josef, Haiman, Christopher A., Yan, Chunli, Henderson, Brian E., Frenkel, Baruch, Barretina, Jordi, Bass, Adam, Tabernero, Josep, Baselga, José, Regan, Meredith M., Manak, J. Robert, Shivdasani, Ramesh, Coetzee, Gerhard A., Freedman, Matthew L.
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763485/
https://ncbi.nlm.nih.gov/pubmed/19561607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.403
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