The 8q24 cancer risk variant rs6983267 demonstrates long-range interaction with MYC in colorectal cancer

An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that this region is a transcriptional enhancer, that the risk region physically interacts with the MYC proto-oncogene, and that the alleles of rs6983267 differentially bind t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Pomerantz, Mark M., Ahmadiyeh, Nasim, Jia, Li, Herman, Paula, Verzi, Michael P., Doddapaneni, Harshavardhan, Beckwith, Christine A., Chan, Jennifer A., Hills, Adam, Davis, Matt, Yao, Keluo, Kehoe, Sarah M., Lenz, Heinz-Josef, Haiman, Christopher A., Yan, Chunli, Henderson, Brian E., Frenkel, Baruch, Barretina, Jordi, Bass, Adam, Tabernero, Josep, Baselga, José, Regan, Meredith M., Manak, J. Robert, Shivdasani, Ramesh, Coetzee, Gerhard A., Freedman, Matthew L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763485/
https://ncbi.nlm.nih.gov/pubmed/19561607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.403
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados