The 8q24 cancer risk variant rs6983267 demonstrates long-range interaction with MYC in colorectal cancer

An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that this region is a transcriptional enhancer, that the risk region physically interacts with the MYC proto-oncogene, and that the alleles of rs6983267 differentially bind t...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Pomerantz, Mark M., Ahmadiyeh, Nasim, Jia, Li, Herman, Paula, Verzi, Michael P., Doddapaneni, Harshavardhan, Beckwith, Christine A., Chan, Jennifer A., Hills, Adam, Davis, Matt, Yao, Keluo, Kehoe, Sarah M., Lenz, Heinz-Josef, Haiman, Christopher A., Yan, Chunli, Henderson, Brian E., Frenkel, Baruch, Barretina, Jordi, Bass, Adam, Tabernero, Josep, Baselga, José, Regan, Meredith M., Manak, J. Robert, Shivdasani, Ramesh, Coetzee, Gerhard A., Freedman, Matthew L.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763485/
https://ncbi.nlm.nih.gov/pubmed/19561607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.403
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki