Tyrosyl-DNA phosphodiesterase and the repair of 3′-phosphoglycolate-terminated DNA double-strand breaks

Although tyrosyl-DNA phosphodiesterase (TDP1) is capable of removing blocked 3′ termini from DNA double-strand break ends, it is uncertain whether this activity plays a role in double-strand break repair. To address this question, affinity-tagged TDP1 was overexpressed in human cells and purified, a...

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Hlavní autoři: Zhou, Tong, Akopiants, Konstantin, Mohapatra, Susovan, Lin, Peck-Sun, Valerie, Kristoffer, Ramsden, Dale A., Lees-Miller, Susan P., Povirk, Lawrence F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763370/
https://ncbi.nlm.nih.gov/pubmed/19505854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2009.05.003
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