Proteasome Inhibition Causes Regression of Leukemia and Abrogates BCR-ABL-Induced Evasion of Apoptosis in Part Through Regulation of Forkhead Tumor Suppressors

BCR-ABL plays an essential role in the pathogenesis of chronic myeloid leukemia (CML) and some cases of acute lymphocytic leukemia (ALL). Even though ABL kinase inhibitors have shown great promise in the treatment of CML, the persistence of residual disease and the occurrence of resistance have prom...

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Detalhes bibliográficos
Main Authors: Jagani, Zainab, Song, Keli, Kutok, Jeffery L., Mariappan, M. Rajan, Melet, Armelle, Santos, Tanya, Grassian, Alexandra, Ghaffari, Saghi, Wu, Catherine, Ren, Ruibao, Miller, Kenneth, Khosravi-Far, Roya
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763358/
https://ncbi.nlm.nih.gov/pubmed/19654305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0605
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