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Simultaneous Monitoring of Peptide Aggregate Distributions, Structure, and Kinetics Using Amide Hydrogen Exchange: Application to Aβ(1–40) Fibrillogenesis
Increasing evidence indicates that soluble aggregates of amyloid beta protein (Aβ) are neurotoxic. However, difficulty in isolating these unstable, dynamic species impedes studies of Aβ and other aggregating peptides and proteins. In this study, hydrogen–deuterium exchange (HX) detected by mass spec...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2763234/ https://ncbi.nlm.nih.gov/pubmed/18351682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.21846 |
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