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How amide hydrogens exchange in native proteins

Amide hydrogen exchange (HX) is widely used in protein biophysics even though our ignorance about the HX mechanism makes data interpretation imprecise. Notably, the open exchange-competent conformational state has not been identified. Based on analysis of an ultralong molecular dynamics trajectory o...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Persson, Filip, Halle, Bertil
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547260/
https://ncbi.nlm.nih.gov/pubmed/26195754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506079112
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