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Binding specificity of Toll-like receptor cytoplasmic domains

MyD88 participates in signal transduction by binding to the cytoplasmic Toll/IL-1 receptor (TIR) domains of activated Toll-like receptors (TLR). Yeast two-hybrid experiments reveal that the TIR domains of human TLR differ in their ability to associate with MyD88: The TIR of TLR2 binds to MyD88 but t...

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Autori principali: Brown, Victoria, Brown, Rachel A., Ozinsky, Adrian, Hesselberth, Jay R., Fields, Stanley
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762736/
https://ncbi.nlm.nih.gov/pubmed/16482509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200535158
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