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Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5

The HSPs (hereditary spastic paraplegias) are genetic conditions in which there is distal degeneration of the longest axons of the corticospinal tract, resulting in spastic paralysis of the legs. The gene encoding spartin is mutated in Troyer syndrome, an HSP in which paralysis is accompanied by add...

詳細記述

保存先:
書誌詳細
主要な著者: Edwards, Thomas L., Clowes, Virginia E., Tsang, Hilda T. H., Connell, James W., Sanderson, Christopher M., Luzio, J. Paul, Reid, Evan
フォーマット: Artigo
言語:Inglês
出版事項: Portland Press Ltd. 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762690/
https://ncbi.nlm.nih.gov/pubmed/19580544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20082398
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